How do omega 3 fats combat inflammation?

[caption id="attachment_488" align="alignnone" width="450" caption="Sardines - Rich in omega 3 fatty acids (and also nucleotides)"][/caption]

The paleo diet seeks to mimic the diet of our human ancestors as they evolved over the last several million years. One of the reasons proposed for copying the ancestral diet is that numerous biochemical pathways have become optimized over time through evolution. On the other hand, the more recent changes to human diet since the start of agriculture (10,000 years ago) and the advent of processed foods (in the last 100 years) have left little time, on the evolutionary scale, for adaptation to occur.

One change that has occurred in modern diets is an increased ratio of omega 6 fats (found in grain feed meat and vegetable oils) to omega 3 fats (found in fish).

This new study seems to provide evidence that a diet rich in omega 3 fatty acids (as anthropological evidence suggests was the case in the ancestral diet) leads to changes in gene expression which result in a lessened tendency for allergic inflammation and autoimmune disorders.

For the past century, changes in the Western diet have altered the consumption of omega-6 fatty acids (w6, found in meat and vegetable oils) compared with omega-3 fatty acids (w3, found in flax and fish oil). Many studies seem to indicate this shift has brought about an increased risk of inflammation (associated with autoimmunity and allergy), and now using a controlled diet study with human volunteers, researchers may have teased out a biological basis for these reported changes.

Anthropological evidence suggests that human ancestors maintained a 2:1 w6/w3 ratio for much of history, but in Western countries today the ratio has spiked to as high as 10:1. Since these omega fatty acids can be converted into inflammatory molecules, this dietary change is believed to also disrupt the proper balance of pro- and anti- inflammatory agents, resulting in increased systemic inflammation and a higher incidence of problems including asthma, allergies, diabetes, and arthritis.

Floyd Chilton and colleagues wanted to examine whether theses [sic] fatty acids might have other effects, and developed a dietary intervention strategy in which 27 healthy humans were fed a controlled diet mimicking the w6/w3 ratios of early humans over 5 weeks. They then looked at the gene levels of immune signals and cytokines (protein immune messengers), that impact autoimmunity and allergy in blood cells and found that many key signaling genes that promote inflammation were markedly reduced compared to a normal diet, including a signaling gene for a protein called PI3K, a critical early step in autoimmune and allergic inflammation responses.

This study demonstrates, for the first time in humans, that large changes in gene expression are likely an important mechanism by which these omega fatty acids exert their potent clinical effects.